Scientific Articles
Cognitive Support
1) Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model. D. Nuzzo , G. Presti, P. Picone,G. Galizzi,E. Gulotta, S. Giuliano, C. Mannino, V. Gambino, S. Scoglio, and M. Di Carlo. Oxidative Medicine and Cellular Longevity. Volume 2018.
2) Study on the effects of super blue-green algae on the nutritional status and school performance of first, second and third grade children.Sevilla I, Aguirre N.The Nicaragua Report. Cell Tech; 1995.
Healthy Aging
1) Primitive Stem Cells are Present in the Blood of Adult Equines and Increase with Moderate Exercise or Ingestion of the Cyanobacteria, Aphanizomenon Flos-Aquae.George W McCommon, Frank Lochner, Asa C Black Jr, and Henry E Young. 2013. Biology.
2) Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study.Shytle RD, Tan J, Ehrhart J, et al.Med Sci Monit.2010; 16(1): BR1-5.
Immune Health
1) Wild-Harvested AFA Microalgae from Klamath Lake - Cellular and Immune Protection
2) Bioregulatory and therapeutic effects of blue-green algae. Kumar K, Lakshmanan A, and Kannaiyan S. Indian Journal of Microbiology. 2003; 43 (1): 9-16.
3) Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flos-aquae, and Chlorella pyrenoidosa. Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS. Planta Med. 2001; 67: 737-742.
4) Blue-green algae as an immuno-enhancer and biomodulator. Jenson GS, Ginsberg DI, Drapeau C. Journal on Nutraceuticals and Nutrition (JANA). 2001; 3: 24-30.
5) Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. Jensen GS, Ginsberg DI, Huerta P, Citton M, Drapeau C. Journal of the American Nutraceutical Association. 2000; 2 (3): 50-58.
6) Effects of the blue-green algae Aphanizomenon flos-aquae (L.) Ralphs on human natural killer cells. Manoukian R, Citton M, Huerta P, et al. Phytoceuticals: Examining the health benefits and pharmaceutical properties of natural antioxidants and phytochemicals. Massachusetts: International Business Communications, Inc.; 1998.
Antioxidant Production/Support
2) Antioxidant and hepatoprotective activity of Aphanizomenon flos-aquae Linn against paracetamol intoxication in rats. Kuriakose GC, Kurup MG. Indian Journal of Experimental Biology. 2010; 48: 1123-1130.
3) Oxygen radical absorbance capacity of phycocyanin and phycocyanobilin from the food supplement Aphanizomenon flos-aquae. Benedetti S, Benvenuti F, Scoglio S, and Canestrari. Journal of Medicinal Food. 2010; 13 (1): 223-227.
4) Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae. Benedetti S, Benvenuti F, Pagliarani S, Francogli S, Scoglio S, Canestrari F. Life Sciences. 2004; 75: 2353-2362.
Gut Health
1) Influence of Aphanizomenon flos-aquae and two of its extracts on growth ability and antimicrobial properties of Lactobacillus acidophilus DDS-1. Rafaella campana, Veronica Martinelli, Stefano Scoglio, Evelin Colombo, Serena Benedetti, Wally Baffone. LWT - Food Science and Technology. 81 (2017) 291e298.
2) Alteration of the gastrointestinal microbiota of mice by edible blue-green algae. Rasmussen HE, Martinez I, Lee JY, Walter J. Journal of Applied Microbiology. 2009; 107: 1108-1118.
3) Effect of a Klamath algae product (“AFA-B12”) on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study. Baroni L, Scoglio S, Benedetti S, Bonetto C, Pagliarani S, Benedetti Y, Rocchi M, Canestrari F. International Journal for Vitamin and Nutrition Research. 2009 Mar;79(2):117-23. doi: 10.1024/0300-9831.79.2.117.
4) Evaluation of renoprotective effect of Aphanizomenon flos-aquae on cisplatin-induced renal dysfunction in rats. Kuriakose GC, Kurup MG. Renal Failure. 2008; 30: 717-725.
5) The effect of blue-green algae Aphanizomenon flos-aquae on nutrient assimilation in rats. Kushak R, Drapeau C, Winter H. Journal on Nutraceuticals and Nutrition (JANA). 2001; 3:35-39.